Arrestins as adaptors for ubiquitination in endocytosis and sorting

Arrestins as adaptors for ubiquitination in endocytosis and sorting.

Arrestins as adaptors for ubiquitination in endocytosis and sorting Endocytosis is the process by which cells internalize portions of their cell membrane along with embedded proteins. these membrane proteins can be recycled back to the plasma membrane from the endosomal compartments to be reused or, alternatively, follow a degradative pathway to the lysosomes. Seven transmembrane receptors (7tM...

Arrestins as adaptors for ubiquitination in endocytosis and sorting

Adapting for endocytosis: roles for endocytic sorting adaptors in directing neural development

Proper cortical development depends on the orchestrated actions of a multitude of guidance receptors and adhesion molecules and their downstream signaling. The levels of these receptors on the surface and their precise locations can greatly affect guidance outcomes. Trafficking of receptors to a particular surface locale and removal by endocytosis thus feed crucially into the final guidance out...

Lipid Raft-Dependent FcεRI Ubiquitination Regulates Receptor Endocytosis through the Action of Ubiquitin Binding Adaptors

The best characterized role for ubiquitination of membrane receptors is to negatively regulate signaling by targeting receptors for lysosomal degradation. The high affinity receptor for IgE (FcepsilonRI) expressed on mast cells and basophils is rapidly ubiquitinated upon antigen stimulation. However, the nature and the role of this covalent modification are still largelly unknown. Here, we show...

Endocytosis and molecular sorting.

Endocytosis in eukaryotic cells is characterized by the continuous and regulated formation of prolific numbers of membrane vesicles at the plasma membrane. These vesicles come in several different varieties, ranging from the actin-dependent formation of phagosomes involved in particle uptake, to smaller clathrin-coated vesicles responsible for the internalization of extracellular fluid and rece...